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Monday, September 5, 2011

Bioinformatics: Feeling the forward Momentum

The past few years in the life science research included collection of hoards of data. A crucial challenge in the future of bioinformatics involves putting that data to work. now life scientists hope to plan large experiments, collect loads of data, analyze it, compare data between experiments, and eventually combine all of that information to improve basic theories, biotechnology, and medicine. to realize this effect, though, life scientists need tools to make data, keep track of it, run it in models, and more. A series of new techniques and tools will help all biologists feel this forward momentum in bioinformatics. A growing list of novel tools including hardware  and software creates new power for  exploring applied and theoretical life sciences.

Computing in Clusters
computers participate in data analysis,ranging from accessing high throughput data and sequencing single nucleotide polymorphism to analyzing microarrays and experiments in proteomics. The biggest challenge is reducing the dimensionality of these data so that scientists can understand them. to do that, computing should combine data mining with  biological insight. Second, computers can run in-silico models that test biological theories. computing advance relies on tightly coupled clusters of processors. Many processors can be connected with high levels of communication between them to work as a team. Tightly coupled clusters work very well for many applications, including simulating molecular biology, chemical kinetics, protein folding and so on.

Software for Sequencing  
Bioinformatics software play a variety of roles in the general field of sequencing, including assembling genomes and identifying genes and regulatory elements. software also helps investigators analyze similarities and differences between genes and organisms. Several dozen companies including DNASTAR, InforMax and Nonlinear Dynamics create software for manipulating genes and DNA sequences. These softwares perform many tasks: sequence assembly and finishing, primer design, gene discovery and annotation, sequence pair and family alignment with phylogeny, restriction site analysis and mapping, and protein structure analysis.

Integrated Analysis
Proteomics also requires new approaches to bioinformatics. Protein studies often include data from a wide varierty of experiment, including mass spectroscopy, protein chips, and two-dimensional gel electrophoresis. As a result, scientists need tools that keep track of data relate one data set to another. Companies like Amersham Biosciences, Bio-Rad, and Oxford Glycosciences offers those very products. they provide data collection and analysis from various applications, including sequencing, microarrays and proteomics. 
      

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